Inhibition of S1P receptor signal transduction by extracellular alpha-synuclein

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07930
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kobe University
• Principal Investigator: OKADA TARO 神戸大学, 医学研究科, 准教授 (80304088)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: α－シヌクレイン / S1P受容体

Outline of Final Research Achievements

Alpha-synuclein (ASN) is considered to be involved in the pathogenesis of Parkinson's disease. ASN is know to be localized outside of neurons but its physiological and/or pathological relevance has not known. In this study I showed extracellular ASN inhibits S1P1 receptor-G protein coupling for the first time. Interestingly the effect of ASN was specific to S1P1 receptor and S1P2 receptor-G protein coupling was not inhibited by extracellular ASN at all. Majority of S1P1 receptor is localized in raft fraction in the cells and extracellular ASN treatment cause "exit" of S1P1 receptor from the raft fraction. These results are important because specific action of extracellular ASN has not been known and we already reported that S1P1 receptor plays important role in hippocampal neurons.

Free Research Field

細胞生物学