2017 Fiscal Year Final Research Report
Development of an antibacterial activity enhancer that restores lost antibacterial activity
| Project/Area Number |
15K07932
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hiroshima University (2016-2017)
Okayama University (2015) |
|---|
Principal Investigator |
Kuroda Teruo 広島大学, 医歯薬保健学研究科(薬), 教授 (80304327)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | topoisomerase / vancomycin / キノロン |
|---|
| Outline of Final Research Achievements |
The action mechanism of compound K on MRSA and VRE was investigated. Compound K inhibited topoisomerase IV of Staphylococcus aureus. However, this action mechanism was different from both ciprofloxacin and novobiocin, already known inhibitors of topoisomerase IV. Compound K also showed the combined effect with vancomycin. Expression of vancomycin resistant cluster genes was not inhibited with compound K, and exposure to compound K restored D-alanyl-D-alanine in VRE cells.
|
| Free Research Field |
微生物学
|
