2017 Fiscal Year Final Research Report
Analysis of Prostate Stem Cell Antigen (PSCA) dependent mechanism of pancreatic cancer
| Project/Area Number |
15K07942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Yokohama College of Pharmacy (2016-2017)
Kitasato University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 膵臓がん / PSCA / 3D培養 |
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| Outline of Final Research Achievements |
Prostate Stem Cell Antigen (PSCA) is expressed in pancreatic cancer tissue and considered as the crucial factor for cancer metastasis. In this study, we established the new culture method of pancreatic cancer cells using cell repellent culture dishes. In this 3D condition, human pancreatic cancer cell KMP2 expressed the high level of PSCA mRNA and protein. In this connection, we identified Numb as one of PSCA regulating factor. In addition, microarray analysis revealed that the expressions of several genes, which reported to be highly expressed in metastatic pancreatic cancer tissue, were up-regulated in KMP2 cultured using 3D method. In these genes, some genes are also regulated by Numb.
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| Free Research Field |
病態生理 腫瘍学
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