2017 Fiscal Year Final Research Report
The novel roles of O-glycans in hypothalamus-pituitary axis
| Project/Area Number |
15K07954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小西 守周 神戸薬科大学, 薬学部, 教授 (00322165)
黒坂 光 京都産業大学, 総合生命科学部, 教授 (90186536)
加藤 啓子 京都産業大学, 総合生命科学部, 教授 (90252684)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロラクチン / ドーパミン / 成長ホルモン / 下垂体 |
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| Outline of Final Research Achievements |
The secretion of the anterior pituitary hormone such as growth hormone and prolactin is strictly controlled by the endocrine signal from the hypothalamus. The elucidation of the pituitary control mechanisms is an important medical interest because it leads to the elucidation of the cause of intractable diseases caused by abnormal secretion of the pituitary anterior lobe hormone and the development of therapeutic methods. In this study, we found that Galnt17 plays an important role in maintaining the function of dopamine nerve projecting from the midbrain ventral to the striatum through analysis of Galnt17 mutant mice and others.
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| Free Research Field |
分子生物学
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