Role of zinc and zinc transporters in the progression of breast cancers

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07955
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Mukogawa Women's University
• Principal Investigator: Takatani-Nakase Tomoka (高谷朋夏) 武庫川女子大学, 薬学部, 准教授 (40434807)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 亜鉛トランスポーター / 亜鉛 / 乳がん / 悪性化進展 / Bcl-2 / YC137 / 細胞死 / オートファジー

Outline of Final Research Achievements

Zinc and zinc transporters are key molecules in malignant progression and might lead to novel strategies for the diagnosis and therapy of breast cancer. In this study, we elucidated the novel mechanism underlying estrogen receptor-positive human breast cancer progression involving zinc and zinc transporters (ZIP6). We also demonstrated that the efficacy of anti-breast cancer drugs was controlled by the regulation of zinc action through ZIP6 without the damage to normal cellular functions. Therefore, we propose to provide novel strategies for therapy of breast cancer using zinc network.

Free Research Field

生物系薬学