2017 Fiscal Year Final Research Report
Novel regulatory mechanism for metabolic syndrome based on extracellular phospholipid metabolism.
Project/Area Number |
15K07959
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | The University of Tokyo (2017) Tokyo Metropolitan Institute of Medical Science (2015-2016) |
Principal Investigator |
Sato Hiroyasu 東京大学, 大学院医学系研究科(医学部), 特任助教 (50546629)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | メタボリックシンドローム / リン脂質代謝 / ホスホリパーゼA2 / 脂肪酸 / 脂肪細胞ベージュ化 |
Outline of Final Research Achievements |
Recent genetic studies have revealed that individual sPLA2s, which show distinct tissue distributions and substrate preferences, participate in diverse biological events in response to given microenvironmental cues. However, the regulatory roles of sPLA2s in metabolic disorders are not well understood. In this study, I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism. We found that (1) sPLA2-IID contributes to metabolic health by mobilizing polyunsaturated fatty acids in white adipose tissue; (2) ablation of sPLA2-III in epidermis ameliorates metabolic syndrome; (3) sPLA2-X, which is highly expressed in the colon epithelium plays a role in amelioration of metabolic syndrome.
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Free Research Field |
脂質生化学
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