2017 Fiscal Year Final Research Report
The molecular mechanisms underlying release and signaling of microparticle in the vascular diseases of diabetic states.
| Project/Area Number |
15K07975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 血管機能障害 / マイクロパーテイクル / 細胞外小胞 / 糖尿病 / 血管機能 |
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| Outline of Final Research Achievements |
Microparticles (MPs) have been described as biological vectors of vascular diseases in other pathologies. I investigated the role of MPs derived from diabetic states in vascular diseases. I found that circulating MPs isolated from diabetic rats impair the endothelial function in response to ACh by directly reducing eNOS expression in carotid arteries. The results strongly suggest that MPs affect endothelial NO vasorelaxation by regulating the protein expressions of eNOS and caveolin-1. I found that high glucose and Ang II directly affect endothelial cells and the production of MPs and indicate involvement of a novel ERK1/2 pathway; the resultant MPs aggravate endothelial dysfunction by regulating eNOS protein levels and ERK1/2 signalling in mice aortas. Reducing numbers of circulating MPs or blocking their effects by inhibiting ERK1/2 activation may offer effective therapeutic approaches for treating endothelial dysfunction in diabetes patients.
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| Free Research Field |
血管機能障害の解明
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