Modulation of cough reflec byf tast 2 receptors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Hoshi University
• Principal Investigator: Kamei Junzo 星薬科大学, 薬学部, 教授 (40161236)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 苦味受容体 / 咳嗽反射 / 気道収縮

Outline of Final Research Achievements

There are at least two mechanisms for the development chronic coughs. One is the enhanced excitability of cough receptors which caused an atopic cough. Another is contraction of the airway smooth muscle which caused cough variant asthma COPD. The aim of this study is to elucidate the Taste 2 receptors (TAS2R) mediated-neuronal networks which involved in the modulation of the excitability of cough receptor by airway contraction. The results of this research suggest that TR2R receptor activation may inhibit the airway contraction-induced cough hypersensitivity through the ATP-sensitive K+ channels.

Free Research Field

薬理学・薬物治療学