2017 Fiscal Year Final Research Report
Roles of lymphocytic cholinergic system in T cells in regulation of the differentiation of naive T cells via muscarinic acetylcholine receptors
| Project/Area Number |
15K07979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
FUJII TAKESHI 同志社女子大学, 薬学部, 教授 (80255380)
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| Co-Investigator(Kenkyū-buntansha) |
間下 雅士 同志社女子大学, 薬学部, 助教 (30738886)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASHIMA KOICHIRO 北里大学, 薬学部, 客員教授 (70095008)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Acetylcholine / T cell / muscarinic receptor / naive T cell / Ca2+ |
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| Outline of Final Research Achievements |
We investigated roles of muscarinic acetylcholine (ACh) receptor (mChR) in T lymphocytes in the differentiation of naive T cells. It has been shown that the activation of naive T cells affects the intracellular signaling system mediated by mAChR. However, it was revealed that mAChR is not involved in regulation of the differentiation of naive helper T cells, while α7 type nicotinic ACh receptor regulates that.
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| Free Research Field |
薬理学
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