2017 Fiscal Year Final Research Report
Molecular mechanisms of hair follicle formation by Runx family proteins
| Project/Area Number |
15K07980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 毛包 / Tnfrsf19 / Shh / ケラチノサイト / 毛乳頭細胞 / Runxファミリー |
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| Outline of Final Research Achievements |
Shh is a morphogenetic factor that is extremely important for hair formation. The mechanism upstream of Shh signal in early anagen was not clear. Expression pattern analysis of Tnfrsf 19 and transplantation test by patch method of genetically modified cells showed that the Tnfrsf 19 signal functions upstream of the Shh signal and is expressed in epidermal keratinocytes. We also found conditions under which Tnfrsf 19 expression is enhanced in cultured keratinocytes. These results provide a novel mechanism of the Tnfrsf 19-Shh pathway in the early stage of hair follicle formation.
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| Free Research Field |
薬理学
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