2017 Fiscal Year Final Research Report
Basic, practical and pioneer research on the treatment of allergic diseases using antigen-specific monoclonal IgA
| Project/Area Number |
15K07985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
Yamaki Kouya 神戸薬科大学, 薬学部, 准教授 (00351768)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | IgA / immunosuppression |
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| Outline of Final Research Achievements |
To investigate the antigen-specific immunosuppressive roles of IgA on various species, we determined the DNA sequences of variable regions of mouse anti-ovalbumin IgA, which showed immunosuppressive effect in mice. Then the antibody secreting cell was established by transfecting the human IgA2 and kappa constant regions expressing vectors inserted with the sequences of the determined variable regions. In addition, we clarified that the immunosuppressive effects of mouse IgA on immune reaction in mice were, at least partly, mediated through antigen neutralization blunting B cell activation.
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| Free Research Field |
免疫薬理
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