Determining factors for giving structural diversity and analysis of temporospatial dynamics of onjisaponins

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07992
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: University of Toyama
• Principal Investigator: Lee Jung-Bum 富山大学, 大学院医学薬学研究部(薬学), 助教 (40332655)
• Co-Investigator(Kenkyū-buntansha): 山村 良美 富山大学, 大学院医学薬学研究部(薬学), 助教 (30464027)
• Co-Investigator(Renkei-kenkyūsha): YAMAGAKI Tohru 公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (40313209)
• Research Collaborator: TATSUO Yoshiaki ; TAKAO Yasumasa ; MURAKAMI Yoshiya
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: オンジ / サポニン生合成

Outline of Final Research Achievements

Onji is an important crude drug for demantia, and onjisaponins are suggested to contribute for the activity. In the present study, important enzyme genes responsible for onjisaponin biosynthesis in Polygala tenuifolia were examined by transcriptomic analyses based on next generation sequencing techniques. As results, a series of gene candidates responsible for saponin biosynthesis has been identified, and characterized their functions. in conclusion, it has been found that important enzyme genes responsible for onjisaponin biosynthesis.

Free Research Field

天然物化学