2017 Fiscal Year Final Research Report
Evaluation of Kampo Prescriptions as Therapeutic Agents for Glucose Metabolism Disorders
| Project/Area Number |
15K08003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Toho University |
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Principal Investigator |
KOIKE Kazuo 東邦大学, 薬学部, 教授 (30130363)
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| Co-Investigator(Kenkyū-buntansha) |
李 巍 東邦大学, 薬学部, 准教授 (90328633)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 医療用漢方製剤 / 糖代謝異常疾患 / 麻子仁丸 / 漢方薬 |
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| Outline of Final Research Achievements |
The study comprehensively evaluated the effects of all oral Kampo preparations on the molecular targets in glucose metabolism disorders. As a result,Daiokanzoto, Masiningan, Tokakujokito, Keimakakuhanto and Choijokito exhibited the highest inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a molecular target for insulin-resistant type 2 diabetes mellitus. On the other hand, Shin'iseihaito and Jidabokuippo showed inhibitory activity against advanced glycation end products (AGEs) and aldose reductase (AR) for diabetic complications, respectively. Furthermore,Tsudosan,Daisaiko and Masiningan showed the strongest antioxidant activity.
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| Free Research Field |
生薬学
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