2017 Fiscal Year Final Research Report
Synthesis of an Antibacterial Compound for Helicobacter pylori
| Project/Area Number |
15K08006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
増井 悠 横浜薬科大学, 薬学部, 講師 (70714377)
高橋 孝志 横浜薬科大学, 薬学部, 教授 (80110724)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUI Hisashi 横浜薬科大学, 薬学部薬科学科, 講師 (70714377)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Helicobacter pylori |
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| Outline of Final Research Achievements |
VDP1 is a selective antibacterial compound that targets Helicobacter pylori and does not act on other typical bacteria. Herein, we provide a straightforward and mild one-pot method for the synthesis of VDP1 from vitamin D3. The yield of VDP1 synthesized by the ruthenium-periodate oxidization of the compound generated from the aza-Diels-Alder reaction of vitamin D3 and 4-phenyl-1,2,4-triazoline-3,5-dione was greater than that produced via direct ruthenium-periodate catalytic oxidation of vitamin D3.
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| Free Research Field |
天然物化学
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