2017 Fiscal Year Final Research Report
Search for new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases
| Project/Area Number |
15K08008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Kindai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NINOMIYA Kiyofumi 近畿大学, 薬学総合研究所, 准教授 (10434862)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 難治性炎症性疾患治療薬シーズ / 伝承・伝統薬物資源探索 / 一酸化窒素 / TNF-α / iNOS / Carapa guianensis / Myristica fragrans / Shorea roxburghii |
|---|
| Outline of Final Research Achievements |
To explore new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases from traditional natural resources worldwide, we searched for active constituents that regulate several inflammation reactions caused by over productions of NO and TNF-alfa etc in iNOS-positive cells. As the results, several constituents from the natural resources were investigated as the promissing candidates and their structural requirements and the mode of action were suggested.
|
| Free Research Field |
生薬・天然物化学
|
