2017 Fiscal Year Final Research Report
Search for anti-lifestyle disease principles through the improvement of hyperinsulinemia from medicinal foods
| Project/Area Number |
15K08009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Toshio 近畿大学, 薬学総合研究所, 教授 (10340449)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 糖尿病 / インスリン / コウズク / phenylpropanoid / センキュウ / phthalide / Carapa guianensis / limonoid |
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| Outline of Final Research Achievements |
The aim of this study is to find the compounds that improve hyperinsulinemia from medicinal foods. In results of this study, we found phenylpropanoids from fruit of Alpinia galanga, phthalides from rhizomes of Cnidium officinale, and limonoids from seed oil of Carapa guianensis as bioactive constituents. Reduction of triglyceride contents in HepG2 cells was observed by addition of these compounds in culture medium. Furthermore, only three times administration of phenylpropanoids, 1'S1-acetoxychavicol acetate and 1'S1-acetoxyeugenol acetate isolated from A. galanga, ameliorated glucose tolerance in mice. Additionaly, triglyceride contents in liver was reduced by the administration in mice.
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| Free Research Field |
食品薬学，生薬学
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