2017 Fiscal Year Final Research Report
Discovery of new drug seeds for psychiatric disorders targeting DNA methylation
Project/Area Number |
15K08011
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Natural medicines
|
Research Institution | Setsunan University |
Principal Investigator |
INATOMI Yuka 摂南大学, 薬学部, 助教 (00258089)
|
Co-Investigator(Kenkyū-buntansha) |
荒木 良太 摂南大学, 薬学部, 助教 (90710682)
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Keywords | DNAメチル化 / 生理活性物質 / 天然物化学 / エピジェネティクス |
Outline of Final Research Achievements |
Several studies have suggested that DNA methylation in the promoter regions of Bdnf gene is involved in the development of mood and psychiatric disorders such as depression and schizophrenia. In this study, we established the convenient assay system for evaluation of DNA methylation levels in the bdnf promoter region, by the incorporation of the reporter construct into the genome of Neuro2A cells. The assay system may be a useful screening tool for drug candidates which have DNA demethylation activities.
|
Free Research Field |
天然物化学
|