2017 Fiscal Year Final Research Report
Structure-Activity Relationship and Mechanistic Studies on Sodium 4-phenylbutyrate and its derivatives
| Project/Area Number |
15K08014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐能 正剛 広島大学, 医歯薬保健学研究科(薬), 助教 (00552267)
太田 茂 広島大学, 医歯薬保健学研究科(薬), 教授 (60160503)
酒井 規雄 広島大学, 医歯薬保健学研究科(医), 教授 (70263407)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 化学シャペロン / 構造活性相関 |
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| Outline of Final Research Achievements |
4PBA was valued its properties by 5 kind of assays. We have determined each criteria to compare the properties with those of other derivatives. Forty 4PBA derivatives were designed then purchased or synthesized as its sodium salt. The derivatives were applied for the assays. Coefficient of correlation values were calculated between some parameters and mRNA expression amount. Four and three genes correlated highly with chaperonic activity or HDAC inhibitory activity, respectively.
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| Free Research Field |
創薬化学
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