Development of Inhibitors of Human Parainfluenza Virus for Prevention of Multi-infectious Diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Hiroshima International University
• Principal Investigator: Ikeda kiyoshi 広島国際大学, 薬学部, 教授 (40168125)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI TAKASHI 静岡県立大学, 薬学部, 教授 (20240947) ; TAKAHASHI TADANOBU 静岡県立大学, 薬学部, 准教授 (20405145) ; TOKIWA HIROAKI 立教大学, 理学部, 教授 (10221433)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: シアリダーゼ阻害剤 / 蛍光イメージングプローブ / パラインフルエンザウイルス / シアル酸

Outline of Final Research Achievements

Human parainfluenza virus type 1 (hPIV-1) is a serious pathogen causing upper and lower respiratory disease in infants and young children; however, there are no known effective inhibitors of hPIV-1 infection. We developed a novel fluorescent sialidase substrate, BTP3-Neu5Ac derivatives, which have imaging of sialidase activity by a highly sensitive fluorescent histochemical method. 2. For the synthesis of the potent and selective inhibitors of human parainfluenza virus, we synthesized compounds having guanigyl group and several acyl functions at C-4 position of sialic acid. Compound bearing guanigyl group showed no effect against hPIV, But, compoundd bearing Ac group showed inhibitory activity against hPIV.

Free Research Field

医薬品科学、創薬化学