2017 Fiscal Year Final Research Report
Role of reactive sulfur species and ER stress response in protection against cadmium toxicity
| Project/Area Number |
15K08042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | カドミウム / 活性イオウ分子 / 小胞体ストレス応答 |
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| Outline of Final Research Achievements |
Cadmium has electrophilic property to modify cysteine residues in cellular proteins, resulting in its dysfunction and cytotoxicity. In this study, role of reactive sulfur species such as persulfides/polysulfides and ER stress response in protection against cadmium toxicity was examined. We found that cadmium induces enzymes associated with the production of reactive sulfur species. Also, reactive sulfur species were found to be protective against cadmium toxicity via formation of sulfur adducts of cadmium.
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| Free Research Field |
分子毒性学
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