2017 Fiscal Year Final Research Report
Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
| Project/Area Number |
15K08047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鍜冶 利幸 東京理科大学, 薬学部薬学科, 教授 (90204388)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロテオグリカン / 血管内皮細胞 / バイオオルガノメタリクス |
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| Outline of Final Research Achievements |
Bio-orgaometallics is a research strategy in which organic-inorganic hybrid molecules are used as a tool to analyze biological systems. Based on this strategy, we got hybrid molecules (1,10-phenanthroline with or without zinc or rhodium) from a library of organic-inorganic hybrid molecules. It was found that the expression of syndecan-4, a small heparan sulfate proteoglycan, is induced via the hypoxia-inducible factor-1α/β pathway when prolyl hydroxylase domain-containing protein 2 is inhibited.
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| Free Research Field |
衛生薬学
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