Studies for physiological functions of human CYP3A enzymes and their clinical applications

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Chiba University
• Principal Investigator: Kobayashi Kaoru 千葉大学, 大学院薬学研究院, 准教授 (30255864)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: CYP3A / テストステロン / ノックアウトマウス

Outline of Final Research Achievements

Results of this study showed that remarkable increase in free testosterone in plasma enhanced androgen response in the prostate of Cyp3a-knockout (KO) mice. Increased testosterone levels activated the androgen receptor (AR), resulting in stimulation of cholesterol synthesis in the prostates of Cyp3a-KO mice. In addition, KO of Cyp3a genes enhanced the synthesis of cholesterol in the liver via activation of SREBP-2 by reduction of 25-hydroxycholesterol. These findings suggest that CYP3A is a regulator for androgen response in the prostate and for synthesis of cholesterol in the liver.

Free Research Field

薬物代謝