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2017 Fiscal Year Final Research Report

Functional and structural analyses of organic cation transporter in the intestine.

Research Project

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Project/Area Number 15K08069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionUniversity of Toyama

Principal Investigator

Hshimoto Yukiya  富山大学, 大学院医学薬学研究部(薬学), 教授 (90228429)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords小腸薬物吸収
Outline of Final Research Achievements

To evaluate the substrate specificity of organic cation transporter in the intestine, we examine uptake of 12 cationic compounds in human intestinal LS180 cells. As the results, the uptake was positively correlated with lipophilicity, and negatively correlated with polar surface area of drugs.
Orphan SLC22A15, 17, and 23 were expressed considerably in the intestine. We over-expresed these genes in renal LLC-PK1 or MDCK cells. However, the transport activity of quinidine was not increased in renal cells, suggesting that SLC22A15, 17, and 23 are not the organic cation transporter in the intestine.

Free Research Field

薬物動態学

URL: 

Published: 2019-03-29  

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