2017 Fiscal Year Final Research Report
Mechanism of anti-inflammatory action of self-assembling heparion nanoparticles
| Project/Area Number |
15K08071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ヘパリン誘導体 / 抗炎症反応 / 数理モデリング / 転写因子 / 因子分析 |
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| Outline of Final Research Achievements |
When non-anticoagulant heparin is conjuated with aliphatic amines, it comes to form self-assembling nanomicelles and exhibit remarkable suppressive effect on the production of proinflammatory cytokines in lipopolysaccharide(LPS)-stimulated macrophages. The present study demonstrated that the anti-inflammatory effect can be observed with not only heparin but other glycosaminoglycans, being stronger as their degree of sulfation is higher. In addition, the time-series data of expression of a variety of genes following LPS stimulation were analyzed based on a mathematical model. The quantitative transcription network analysis indicated that the heparin nanoparticles appeared to selectively inhibit the activation of TAK1-IKK-NFkappaB pathway following LPS stimulation.
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| Free Research Field |
薬物送達学
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