2017 Fiscal Year Final Research Report
Study for PK/PD determinant factor of tyrosine kinase inhibitors
| Project/Area Number |
15K08096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shimane University |
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Principal Investigator |
Naora Kohji 島根大学, 医学部, 教授 (90243427)
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| Co-Investigator(Kenkyū-buntansha) |
西村 信弘 島根大学, 医学部, 准教授 (30529657)
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| Research Collaborator |
TAMAKI Hiroki
HONGOH Masafumi
NAKAMURA Takeshi
ISHIHARA Noriyuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | PK/PD / tyrosine kinase / inhibitor |
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| Outline of Final Research Achievements |
In this study, we investigated factors that alter the pharmacokinetics of tyrosine kinase inhibitor (TKI), a therapeutic agent for oral cancer molecular target. As the results, TKI pharmacokinetics was possibly changed by not only drug interaction of hepatic enzyme induction with rifampicin but also fluid retention by serious renal dysfunction. Therefore, it is necessary to pay attention to fluctuation in the pharmacokinetics, such as blood concentration monitoring of TKI, in the patients with concomitant medications or complications such as renal disorder. In addition, it was shown that prescribed amount of topical moisturizer is an important factor for onset of hand-foot syndrome as major adverse effect of TKI, which suggests the importance of pharmaceutical management for TKI-prescribed patients by pharmacists.
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| Free Research Field |
医療薬学
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