2017 Fiscal Year Final Research Report
Development of oral administered liposome contained vitamin B12 via the M cell
| Project/Area Number |
15K08104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉山 育美 岩手医科大学, 薬学部, 助教 (80509050)
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| Co-Investigator(Renkei-kenkyūsha) |
OIKAWA Hiroki 岩手医科大学, 医学部, 講師 (50285582)
NISHIZUKA Satoshi 岩手医科大学, 医学部, 特任教授 (50453311)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | リポソーム / 経口投与 / M細胞 / 悪性貧血 |
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| Outline of Final Research Achievements |
The formulation which be available for oral administration was studied for treating megaloblastic anemia based on deficient vitamin B12 (VB12) by stomach resection of gastric cancer patients, and improvement of patient’s quality of life. Liposome, one of the drug carriers, was selected for taking into the body without gastric intrinsic factor. It was expected that liposome was taken up via the microfold cell (M cell) on Peyer's patch cells of intestinal epithelium cell because the structure of liposome looks like that of virus. VB12 loaded liposome was increased VB12 concentration in serum compared to VB12 solution when mice was orally administered. It was expected that the absorptive process was involved in M cell. Thus, the usefulness of liposome was suggested for treating megaloblastic anemia as orally administrated formulation.
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| Free Research Field |
薬物送達を研究基盤としたリポソームへの機能性付与及び食品成分併用による医薬品の効果増強
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