Comparative studies on the usefulness of over-the-counter drugs

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kyushu University of Health and Welfare
• Principal Investigator: Motoya Toshiro 九州保健福祉大学, 薬学部, 教授 (60166345)
• Co-Investigator(Renkei-kenkyūsha): KAWACHI Akio 九州保健福祉大学, 薬学部, 教授 (80389593) ; SONODA Jyunichiro 九州保健福祉大学, 薬学部, 講師 (00551293) ; NARUMI Keiko 九州保健福祉大学, 薬学部, 助教 (40551304) ; SATO Keizo 九州保健福祉大学, 薬学部, 教授 (00315293) ; SHIMODOZONO Yoshihiro 九州保健福祉大学, 薬学部, 教授 (40758033)
• Research Collaborator: YAMASHITA Shoko ユネット清風薬局, 薬剤師 ; KURASAWA Katsuki 延岡すずらん薬局, 薬剤師 ; SHIMAI Natsumi 延岡すずらん薬局, 薬剤師 ; SHIBATA Masayuki 延岡すずらん薬局, 薬剤師 ; TABATA Koichi タバタ薬局, 薬剤師 ; NISHI Yosuke タバタ薬局, 薬剤師 ; MAEZONO Hiromi タバタ薬局, 薬剤師
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ＯＴＣ薬 / 頭痛 / アレルギー性鼻炎 / 同効薬比較

Outline of Final Research Achievements

We compared the usefulness, such as efficacy and user satisfaction, of over-the-counter (OTC) drugs to treat headaches. No significant differences were observed in efficacy or user satisfaction between 3 groups of medicines containing loxoprofen(G1), ibuprofen(G2), and aspirin or acetaminophen + ethenzamide(G3) as the main analgesic.
We also compared usefulness of OTC drugs for the tratment of allergic rhinitis. Changes in total nasal symptom scores for rhinorrhea, sneezing, nasal congestion, and nasal itching from the baseline with fexofenadine hydrochloride were not significantly different from those with medicines containing chlorpheniramine maleate. None of the four individual symptom scores were significantly different. Furthermore, the incidence of adverse events was not significally different between the two treatments ; however, it was slightly higher with the latter than with the former.

Free Research Field

臨床薬学