2017 Fiscal Year Final Research Report
Roles of retinoic acid in the proepicardium organ formation during chick heart development
| Project/Area Number |
15K08140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 心臓 / 心外膜 / 胚 |
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| Outline of Final Research Achievements |
The proepicardial organ (PEO) arises in the sinus venosus region, and then the cells of the PEO spread over the myocardium. These cells differentiate into the epicardium, the fibroblast, the smooth muscle and the endothelial cells of the coronary vessels. The markers of the PEO, such as WT1 and TBX18, were detected in the PEO presumptive region at stage 14. In vitro PEO assay using stage 11-13 showed the reduce of the differentiation into the PEO. When retinoic acid was administrated in the culture medium of the assay, the expression of WT1 and TBX18 protein was increased.
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| Free Research Field |
発生学
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