function of FoxO1 in lymphangiogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Kagawa Prefectural College of Health Sciences
• Principal Investigator: Furuyama Tatsuo 香川県立保健医療大学, 教養部, 教授 (20238702)
• Co-Investigator(Kenkyū-buntansha): 稲垣 忍 大阪大学, 医学系研究科, 教授 (90151571)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リンパ管形成 / CXCR4 / Foxo1

Outline of Final Research Achievements

Lymphangiogenesis is involved in many pathophysiology; cancer metastasis, inflammation and lymphedema. In this study, we carried out examination of lymphangiogenesis in tail dermis after birth using mouse model. The specific deletion of FoxO1 in endothelial cells lead to impaired formation of lymphatic vessel network through defects in migration and proliferation of endothelial cells. Moreover, we identified CXCR4 as a candidate of causative gene of this defective phenotype, which was most significantly decreased by reduction of FOXO1 in lymphatic endothelial cells. These findings suggested that Foxo1 and target genes play important roles in lymphangiogenesis.

Free Research Field

形態形成