2017 Fiscal Year Final Research Report
Investigation into neural network of cardiorespiratory interactions
| Project/Area Number |
15K08171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
|
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| Research Institution | University of Tsukuba |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 循環調節 / 高血圧 / 交感神経 / 呼吸循環連関 |
|---|
| Outline of Final Research Achievements |
This project demonstrated that in hypertensive rats, reduction of inspiratory hyperpolarization on the cardiovascular sympathetic premotor neurons (RVLM neurons) enhances respiratory activity of the cardiovascular sympathetic nerve. And, the reduction of inspiratory hyperpolarization on RVLM neurons is caused by activation of excitatory inputs to the RVLM neurons. Moreover, the respiratory modulation into RVLM neurons in eupnea is maintained by endogenous hydrogen sulfide which is produced by hydrogen sulfide synthase.
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| Free Research Field |
自律神経生理
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