Elucidation of the mechanism of sinus node dysfunction occurrence in diabetes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Oita University
• Principal Investigator: SHINOHARA TETSUJI 大分大学, 医学部, 助教 (60457629)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / 心房細動 / レプチン

Outline of Final Research Achievements

The patients with diabetes often causes rhythm abnormalities such as sick sinus syndrome and atrial fibrillation. It is considered that the involvement of sinus node cell fibrosis and remodeling. The present study suggests that mast cells contribute to the pathogenesis of hyperglycemia-induced atrial fibrillation via enhancement of inflammation and fibrosis　(Uemura K, Shinohara T, et al. J Cardiovasc Electrophysiol. 2016;27:981-9). Furthermore, we reported that hyperleptinemia induces high-fat diet-mediated atrial fibrosis and fibrillation (Fukui A, Shinohara T, et al. J Cardiovasc Electrophysiol. 2017;28:702-710). In addition, we demonstrated that interleukin 10 can inhibit atrial remodeling and atrial fibrillation caused by a high-fat-diet.

Free Research Field

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