The investigation of CAPS2-dependent secretion of oxytocin

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Tokyo University of Pharmacy and Life Science (2016-2017); Tokyo University of Science (2015)
• Principal Investigator: SHINODA YO 東京薬科大学, 薬学部, 講師 (80403096)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: CAPS / oxytocin

Outline of Final Research Achievements

The aim of this study is to investigate whether CAPS protein contributes oxytocin (OXT) secretion. In this projects’ period, we observed that 1: OXT level was significantly reduced in blood and increased in pituitary in Caps2 KO mice. 2: Similar tendency were observed in Caps2 dex3 mice. 3: The expression and subsequent transportation of OXT into axon terminal in Caps2 dex3 mice were identical to WT. 4: OXT neurons were heterogeneous population, some of them expressed both CAPS1 and 2 but another expressed CAPS1 or 2. 5: OXT neuron specific Caps1 cKO mice showed significant increasing of sociality. Taken together, these result suggest that both CAPS1 and CAPS2 are possibly involved in OXT secretion.

Free Research Field

神経科学