2017 Fiscal Year Annual Research Report

Sex differences in blood pressure regulation - elucidation of the central mechanisms of hypotension in females -

Research Project

Project/Area Number	15K08201
Research Institution	Ochanomizu University
Principal Investigator	グホサビンお茶の水女子大学, 理学部, 学部教育研究協力員 (30453179)
Co-Investigator(Kenkyū-buntansha)	和気秀文順天堂大学, スポーツ健康科学部, 教授 (50274957) 宮本泰則お茶の水女子大学, ヒューマンライフイノベーション研究所, 准教授 (50272737)
Project Period (FY)	2015-04-01 – 2018-03-31
Keywords	NTS / gender / SHR / Blood pressure / microarray / gene expression
Outline of Annual Research Achievements	To assess whether NTS function could contribute to the gender difference in arterial pressure (AP) regulation, gene expression in the nucleus tractus solitari (NTS) of Spontaneous Hypertensive Rats (SHRs) was investigated by using microarray. Results showed that the transcript expression of TRPV4 (Transient receptor potential cation channel subfamily V member 4), a channel involved in brain fluid and ion homeostasis control, was significantly increased in the NTS of female SHRs compared to males. Estrogen treatment did not affect TRPV4 expression in the NTS and TRPV4 agonist 4alpha-PDD injected into the NTS of female SHRs decreased AP, suggesting that TRPV4 might be involved in the gender differences of AP via an estrogen-independent alteration of its expression level in the NTS of SHRs.

(4 results)