2017 Fiscal Year Final Research Report
Regulation of the m2 muscarinic ACh receptor-mediated signaling by RGS proteins
| Project/Area Number |
15K08231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KURACHI Yoshihisa 大阪大学, 大学院医学系研究科, 教授 (30142011)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 細胞内シグナル伝達 / 受容体 / カリウムチャネル / G蛋白質シグナル / 電気生理学 |
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| Outline of Final Research Achievements |
Activation of the m2 muscarinic acetylcholine receptor (m2R) in cardiomyocytes induces the potassium channel opening via the G protein signaling system. This is a molecular mechanism of heart rate control. It has been known that regulators of G protein signaling 4 (RGS4) regulates this intracellular signal transduction system. In this study, we investigated the role in determining the signal transduction efficacies of m2R partial agonists such as pilocarpine. As a result, we found that RGS4 is essential for the characteristics mode of action of m2R partial agonist, such as its voltage dependence, and clarified a part of the structural basis of the underlying mechanism.
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| Free Research Field |
薬理学
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