Regulation of ischemic organ injury by endothelin and estrogen and sex difference

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08252
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka University of Pharmaceutical Sciences
• Principal Investigator: Ohkita Mamoru 大阪薬科大学, 薬学部, 准教授(移行) (60449824)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エンドセリン / エストロゲン

Outline of Final Research Achievements

There are significant sex difference in ischemic acute kidney injury (AKI). A selective endothelin (ET) A receptor antagonist showed renoprotective effects in male but not female AKI rats. In addition, there was a clear difference in the effects of selective ETA receptor antagonist depending on the presence or absence of female sex hormones, suggesting that ET-1/ETA receptor system is closely involved in the pathogenesis of AKI and sex difference in AKI. Furthermore, from the studies using ETB receptor-deficient rats, it became clear that ETB receptor also plays an important role in gender difference of AKI.

Free Research Field

基礎医学・薬学（薬理学）