Selective gene expression machinary during prolonged phase of hypoxia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08260
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKAYAMA Koh 東京医科歯科大学, 難治疾患研究所, 准教授 (10451923)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 低酸素応答 / 転写因子 / CREB / 遺伝子発現

Outline of Final Research Achievements

We have identified that CREB becomes activated during prolonged phase of hypoxia. In this study, we aimed to understand how CREB regulates its target genes specifically under the prolonged hypoxic condition. I first compared control and CREB-KD cells, and identified a gene set which is specifically induced during prolonged phase of hypoxia. GO analysis of the gene set revealed many gene groups which are involved in malignant transformation of cancer. Finally, lung metastasis was highly inhibited in CREB-KD cells, indicating that CREB activation is involved in tumor metastasis.

Free Research Field

細胞医科学