Comprehensive study on transcriptional induction mechanisms and pathological significance of glycan-related genes by hypoxia inducible factor, HIF

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Aichi Medical University
• Principal Investigator: Kannagi Reiji 愛知医科大学, 公私立大学の部局等, その他 (80161389)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 低酸素 / 糖鎖関連遺伝子 / CD44 / ヒアルロン酸 / micro-RNA / 転写調節 / HIF-1α

Outline of Final Research Achievements

Hypoxia-resistant cancer cells are known to have highly malignant characteristics, frequently undergo metastasis, and are resistant to chemotherapy. We are long studying induction mechanisms of glycan-related genes by a transcription factor HIF, which plays a key role in acquisition of hypoxia resistance. In this project we clarified that HYAL1, which encode a degradation enzyme for hyaluronic acid, the CD44 ligand, is induced by hypoxia and is a good target for cancer therapy. We also identified GCNT2 gene to be regulated by microRNA miR-199 under hypoxia, and is also a good target for cancer therapy.

Free Research Field

生化学、腫瘍学