2017 Fiscal Year Final Research Report
Mechanism involved in resistance to diet-induced obesity observed in protein phosphatase PPM1L knockout mice.
| Project/Area Number |
15K08293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロテインホスファターゼ |
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| Outline of Final Research Achievements |
Obesity is major risk factor for diabetes and cardiovascular diseases. In an earlier study using quantitative trait loci (QTL) analysis in mice, protein phosphatase Ppm1l was identified as a gene connected to obesity and other metabolic syndrome traits (Chen et al, 2008), but the underlying mechanism remains unclear. PPM1L-KO mice were protected against high fat diet-induced obesity. This was partly due to diminished food intake. PPM1L-KO mice exhibit morphological abnormalities in the central nerve system including reduction of striatum, corpus callosum and anterior commissure, suggesting that defect of neural network in CNS may result in reduced appetite. Using recently described proximity-dependent biotin labeling (BioID) technique, a number of nuclear envelope associated proteins were identified as interacting partner of PPM1L.
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| Free Research Field |
生化学
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