Development of therapeutic strategy based on autophagy activity for cancer therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INOUE Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: オートファジー

Outline of Final Research Achievements

It is needed for development of novel therapeutic strategy based on autophagy activity in tumor from individual patients for cancer therapy. In this study, we found that 1) high expression of p62 protein, an autophagic substrate, may be a possible biomarker for autophagy-impaired cancers, 2) miR-634 has a tumor-suppressive function by concurrently targeting multiple cytoprotective processes including autophagy, 3) autophagy inhibition leads to an increased sensitivity to L-asparaginase in acute lymphoblastic leukemia (ALL). These findings provide novel insight for development of novel therapeutic strategy based on autophagy activity for cancer therapy.

Free Research Field

腫瘍生物学