2017 Fiscal Year Final Research Report
Roles of tenascin-C in stromal formation of breast cancers
| Project/Area Number |
15K08344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小塚 祐司 三重大学, 医学部附属病院, 講師 (50378311)
田中 典子 (花村典子) 三重大学, 医学部附属病院, 講師 (60437100)
野呂 綾 三重大学, 医学部附属病院, 助教 (00747173)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | テネイシン－C / 癌間質 / マクロファージ / 筋線維芽細胞 |
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| Outline of Final Research Achievements |
Tenascin-C (TNC) is highly expressed in cancer stoma which may be responsible for cancer progression. The aim of this study is to clarify TNC roles in formation of the breast cancer stroma composed of fibroblasts, including myofibroblasts and cancer-associated fibroblasts, and macrophages. In macrophages, TNC promotes the migration, cytokine expression, and induction to M1 repertory. TNC also enhances myofibroblast trans-differentiation, gel contraction activity, and TNC production in fibroblasts. Thus, TNC may significantly contribute to the stromal formation of the breast cancer.
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| Free Research Field |
人体病理学
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