Molecular pathological analysis of salivary gland carcinomas

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: Inagaki Hiroshi 名古屋市立大学, 大学院医学研究科, 教授 (30232507)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 分子病理学 / 粘表皮癌 / 腺様嚢胞癌 / 分泌癌 / 唾液腺腫瘍

Outline of Final Research Achievements

In this study, we focused on mucoepidermoid carcinoma, adenoid cystic carcinoma, and mammary-analogue secretory carcinoma of the salivary gland. In mucoepidermoid carcinomas, we proposed a novel variant, Warthin-like mucoepidermoid carcinoma; clarified clinicopathological significance of amphiregulin overexpression; and pointed out that postoperative radiotherapy may not be necessary for early stage, CRTC1/3-MAML2-positive cases. In adenoid cystic carcinomas, we clarified clinicopathological significance of gene rearrangements associated with MYB, MYBL1, and NFIB genes, and abnormalities of genes involved in the EGFR signaling pathway. In mammary-analogue secretory carcinomas, we detected a novel chromosomal alteration other than classical ETV6-NTRK3.

Free Research Field

分子病理学　唾液腺腫瘍　悪性リンパ腫