Analysis of antioxidant-related AMPK pathway in the onset and progression of non-alcoholic steatohepatitis (NASH).

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Iwate Medical University
• Principal Investigator: OIKAWA KANTA 岩手医科大学, 医学部, 研究員 (00405804)
• Co-Investigator(Kenkyū-buntansha): 増田 友之 岩手医科大学, 医学部, 教授 (10199698) ; 前沢 千早 岩手医科大学, 医学部, 教授 (10326647) ; 及川 浩樹 岩手医科大学, 医学部, 講師 (50285582)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: NASH / AMPK / SOD2 / Catalase / 8OHdG

Outline of Final Research Achievements

Thirty seven cases of NASH and forty cases of NAFL were immunohistochemically examined. 8OHdG and 4-HNE which was oxidation stress-related were over expression in NASH. SOD2 and Catalase which was antioxidation-related on NASH were not recognize significant difference compared with NAFL. The protein and mRNA with NASH model in a cultured cell showed over expression on LKB1, AMPK, FOXO3a. However SOD2 and Catalase were not recognized significant difference. Knockdown of the AMPK induced the inhibition of FOXO3a, SOD2 and Catalase.

Free Research Field

肝臓内科　肝臓病理　消化器癌 消化器内科