2017 Fiscal Year Final Research Report
A cell lineage of breast cancer consisting of different histologic types by mutation analysis of mtDNA D-loop region
| Project/Area Number |
15K08357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ESUMI Mariko 日本大学, 医学部, 客員教授 (10147019)
TOU Shoen 日本大学, 医学部, 准教授 (20326036)
AMANO Sadao 日本大学, 医学部, 客員教授 (80159459)
SAKURAI Kenichi 日本大学, 医学部, 准教授 (20366602)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 乳癌 / 細胞系譜 / 乳管癌 / 小葉癌 / ミトコンドリアDNA / 組織型 |
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| Outline of Final Research Achievements |
The aim of study was to reveal cell lineage of cancer cells behind the characteristics of pathological morphology. Combined lobular and ductal carcinomas were submitted to this study. Genetic alteration of D-loop region of mitochondrial DNA and 409 nuclear genes were analyzed. Closely located cancer cells have a possibility to be originated from an identical cancer cell even though cancer cells were classified into different histological types. It is also suggested that cancer cells far from each other in different segments might be different cell origin, even though they were classified into the same histological type. This study enables us to look into the cell lineage of cancer cells in relation to histological type.
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| Free Research Field |
人体病理学
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