Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Aichi Medical University
• Principal Investigator: KASAI KENJI 愛知医科大学, 医学部, 教授 (70242857)
• Co-Investigator(Renkei-kenkyūsha): IKEDA HIROSHI 愛知医科大学, 医学部, 教授 (00131219) ; INAGUMA SHINGO 愛知医科大学, 医学部, 講師 (80410786) ; ITO HIDEAKI 愛知医科大学, 医学部, 助教 (90711276)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 乳癌 / 遺伝子制御 / Hedgehog / TSHZ2 / FAM64A

Outline of Final Research Achievements

I identified TSHZ2 as a down-regulated gene during breast carcinogenesis. TSHZ2 was found to make a ternary complex with GLI1 and CtBP2 in the nucleus of normal duct epithelium and suppress the target gene expression of GLI1. This indicates that down-regulated TSHZ2 and in turn up-regulated target genes of GLI, such as CXCR4 and AEBP1, would be responsible for breast cancer progression.
I next identified FAM64A, FAM83D, DLGAP5, FOXM1 and DONSON as candidates of TSHZ2 target genes. Especially, I found that FAM64A associates with several nuclear proteins which are involved in chromatin remodeling and DNA replication.

Free Research Field

人体病理学