2017 Fiscal Year Final Research Report
Possible role of nuclear b-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer
| Project/Area Number |
15K08385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
Saegusa Makoto 北里大学, 医学部, 教授 (00265711)
Hashimura Miki
Nakamura Kie
Usami Akane
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 癌幹細胞 / 化学放射線療法 / 上皮間葉転換 / 直腸癌 / β-カテニン |
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| Outline of Final Research Achievements |
A total of 109 cases of locally advanced rectal cancer, along with a colon cancer cell line, were investigated. Nuclear β-catenin accumulation in pretreatment-biopsied samples was inversely associated with the therapeutic efficacy of chemoradiotherapy in resected rectal cancer. Nuclear β-catenin was predominantly observed in EMT-like lesions with decreased E-cadherin and increased Snail expression, along with expression of CSC-related markers. The EMT-like lesions also showed significant decreases in both apoptosis and cell proliferation. In-vitro, induced EMT/CSC properties together with nuclear β-catenin accumulation showed inhibition of cell proliferation and resistance to doxorubicin treatment.
Nuclear β-catenin accumulation may contribute to chemoradioresistance, probably through its regulation of EMT/CSC properties. In addition, nuclear β-catenin in pretreatment-biopsied samples is useful in predicting the efficacy of chemoradiotherapy in patients with rectal cancer.
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| Free Research Field |
消化管病理
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