2017 Fiscal Year Final Research Report
BMP-4 as a new therapeutic target in colorectal cancer
Project/Area Number |
15K08393
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Ehata Shogo 東京大学, 大学院医学系研究科(医学部), 特任准教授 (90506726)
|
Research Collaborator |
Yokoyama Yuichiro 東京大学, 大学院医学系研究科, 特任研究員
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | Colorectal cancer / Apoptosis / BMP-4 / Erk MAPK / DUSP5 |
Outline of Final Research Achievements |
Poor prognoses for colorectal cancer patients with metastatic lesions have driven demand for the development of novel targeted therapies. Here we demonstrate that expression of bone morphogenetic protein 4 (BMP-4) is universally upregulated in human colorectal cancer cells and tissues, resulting in activated BMP signaling. Inhibition of endogenous BMP signaling by the BMP type I receptor inhibitor LDN-193189 elevated expression of the phosphatase DUSP5 in colorectal cancer cells, inducing apoptosis via dephosphorylation of Erk MAPK. Administering LDN-193189 to mice diminished tumor formation of colorectal cancer cells. Our findings suggest inhibition of autocrine BMP-4 as a candidate treatment strategy for colorectal cancer.
|
Free Research Field |
分子腫瘍学
|