2017 Fiscal Year Final Research Report
Overexpression of DDX27 in gastric cancer
| Project/Area Number |
15K08406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
守山 正胤 大分大学, 医学部, 教授 (90239707)
平下 有香 大分大学, 医学部, 医員 (70771955)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 胃癌 / DDX27 |
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| Outline of Final Research Achievements |
Previously, we reported that DDX27 gene is amplified and overexpressed with the progress of gastric carcinogenesis. In this project, we aimed to determine whether DDX27 contributes to malignancy of gastric cancer. Before we started this project, we found that expression of DDX27 is related to colony formation of gastric cancer cells and patients' survival. In this project, we analyzed the impact of DDX27 knockdown on gastric cancer cells and found that 1)DDX27 contributes to tumor formation in vivo, 2)DDX27 regulates cell cycle of gastric cancer cells and 3)DDX27 regulates phosphorylation of Akt. These results contribute to establish a novel molecular targeted therapy in gastric cancer. We reported these data in American Journal of Cancer Research.
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| Free Research Field |
分子病理額
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