Regulation of blood-brain barrier function by membrane-type metalloproteinases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Yamaguchi University
• Principal Investigator: IKEDA EIJI 山口大学, 大学院医学系研究科, 教授 (30232177)
• Co-Investigator(Kenkyū-buntansha): 崔 丹 山口大学, 大学院医学系研究科, 講師 (40346549)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血液脳関門 / claudin-5 / 低酸素 / 炎症 / 糖尿病網膜症

Outline of Final Research Achievements

In various intractable neural diseases, the impairment of neural vascular barriers, including blood-brain barrier, occurs and accelerates their disease progression. As the candidates for target molecules to restore the neural vascular barrier, we have specified ADAM12, ADAM17 and basigin, all of which are expressed in endothelial cells. As for ADAM12 and ADAM17, they were shown to be involved predominantly in hypoxia-induced impairment of vascular barrier, and consequently to be unable to restore sufficiently the vascular barrier in neural diseases in which various stimuli, together with hypoxia, cause the vascular barrier disruption. On the other hand, it was demonstrated that basigin is involved in the impairment of vascular barrier as the common downstream molecule of various stimuli including hypoxia and multiple cytokines, and furthermore our study with animals indicated the potential of basigin as the target to establish the new effective treatment of intractable neural diseases.

Free Research Field

病理学