Development of metabolic syndrome and feeding behavior: analysis in new model mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Nippon Medical School
• Principal Investigator: SUGIHARA Hitoshi 日本医科大学, 大学院医学研究科, 大学院教授 (60183414)
• Co-Investigator(Kenkyū-buntansha): 長尾 元嗣 日本医科大学, 大学院医学研究科, 助教 (10468762)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メタボリックシンドローム / 過食 / 肥満 / 耐糖能異常 / 糖尿病 / マウス / 実験病理学

Outline of Final Research Achievements

In this study, using recently established 2 lines of mice with different susceptibility to high fat diet-induced glucose intolerance, we analyzed the phenotypic differences between the glucose intolerance-prone (Prone) and -resistant (Resistant) mice, focusing on feeding behavior. Here, we identified heritable differences in gene expression, blood plasma level, and signal intensity of leptin between the Prone and Resistant mice as a key factor showing the overeating tendency in Prone mice from the young stage. These results suggest that heritable differences in leptin dynamics play an important role, via overeating, in regulating the development of obesity and metabolic syndrome.

Free Research Field

内分泌代謝内科学