Osteonecrosis of the femoral head in childhood

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Tenri University
• Principal Investigator: Kamiya Nobuhiro 天理大学, 体育学部, 教授 (50735876)
• Research Collaborator: Kim Harry Texas Scottish Rite Hospital, Professor
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨壊死 / 小児 / インターロイキン６ / 大腿骨頭 / ペルテス病 / 動物モデル

Outline of Final Research Achievements

This study focuses on the pediatric osteonecrosis of the femoral head. In order to prevent a collapse of the femoral head, there is a strict limitation of school activity and daily life for children with this disease. Although this disease was first reported over 100 years ago, it still takes several years for the initial treatment. We found that interleukin-6 is abundantly expressed in the hip joint effusion and that some garbage from the dead cells can induce interleukin-6 as a disease mechanism. We think that inhibition of interleukin-6 can improve the disease condition especially for preventing the collapse.

Free Research Field

小児整形外科・骨代謝